Increasing the database cache size can improve system performance but requires additional memory. The minimum number of databases allowed in the cache at one time is 25; the maximum is approximately 2000, depending on the server platform.
These parameters will be automatically configured by the Domino R5 server. They will not be present in the NOTES.INI, but if left they will be supported.
Also, during runtime, be sure to remove any DEBUG settings within NOTES.INI.